Anti-CD38 Mouse Monoclonal Antibody [clone: AT-1] (FITC)

供应商: STEMCELL Technologies
STMC60131FIEA 0 CNY
STMC60131FI
Anti-CD38 Mouse Monoclonal Antibody [clone: AT-1] (FITC)
抗体
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD38, FITC-conjugated.

  • B cells
  • Hematopoietic stem
  • Progenitor cells
  • Plasma

The AT-1 antibody reacts with CD38, an ~45 kDa type II integral membrane glycoprotein that is part of the ADP-ribosyl cyclase family. CD38 is widely expressed at variable levels on hematopoietic cells including early B and T cell lineages, activated B and T cells, NK cells, monocytes, and dendritic cells. It is strongly expressed in plasma cells. CD38 is also expressed in some non-hematopoietic tissues such as brain, kidney, muscle, and pancreas. CD38 is an ectoenzyme that acts as both an ADP-ribosyl cyclase and ADP-ribose (ADPR) hydrolase for the synthesis and hydrolysis of cyclic ADPR (cADPR) and NAADP. cADPR acts as a second messenger for intracellular calcium mobilization to facilitate glucose-induced insulin secretion. It has been shown that the AT-1 antibody mutually competes for binding with OKT10 and SUN-4B7, and all three clones only bind the native (not reduced) form of CD38.

Type:
Antigen: CD38
Clonality: Monoclonal
Clone: AT-1
Conjugation: FITC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Cynomolgus monkey, Human, Rhesus monkey
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